Monday, April 25, 2011

NMO mimicking narcolepsy

Patient with presentation of hypersomnolence with diencephalic lesions with presentation of narcolepsy, diagnosed with CSF NMO after negative serum x 3.  Also had low CSF hypocretin levels.

NMO IgG in CSF with negative serum NMO

Klawiter et al.  Neurology 2009; 72:  1101-1102

Authors present 3 cases of NMO with negative serum and positive CSF diagnostic titers of NMO IgG.  Features include absent ON is all cases, rapidly progressive myelitis,