Jarius S et al. NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 2007;68:1076-77.
NMO IgG was studied in 36 patients with Wingerchuk confirmed clinical criteria for NMO and 80 patients meeting McDonald criteria for MS. 22/36 with NMO and 4/5 with LETM (longitudinally extensive transverse myelitis) had positive antibodies and only one control with MS was positive. Fisher exact test< 0.001. The authors studied a specific pattern of staining in layers of cerebellum including pia and others.