Saturday, April 21, 2007

Confirmation of antibody tests

Jarius S et al. NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 2007;68:1076-77.

NMO IgG was studied in 36 patients with Wingerchuk confirmed clinical criteria for NMO and 80 patients meeting McDonald criteria for MS. 22/36 with NMO and 4/5 with LETM (longitudinally extensive transverse myelitis) had positive antibodies and only one control with MS was positive. Fisher exact test< 0.001. The authors studied a specific pattern of staining in layers of cerebellum including pia and others.

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